Extended-spectrum beta-lactamases (ESBLs)
Extended-spectrum beta-lactamases (ESBLs): treatment, prevention, surveillance
Gov.UK 2013
How to prevent the spread of extended-spectrum beta-lactamase (ESBL) producing E. coli and Klebsiella - and treatment options..
LINK
EUCAST guidelines for detection of resistance mechanisms Version 1.0 December 2013
EUCAST 2013
The recommended strategy for the detection of ESBLs in Enterobacteriaceae is based on non-susceptibility to indicator oxyiminocephalosporins, followed by phenotypic (and in some cases genotypic) confirmation tests.
LINK
EUCAST guidelines for detection of resistance mechanisms Version 2.0 July 2017
EUCAST 2017
Cefpodoxime is the most sensitive individual indicator cephalosporin for detection of ESBL production and may be used for screening. However, it is less specific than the combination of cefotaxime (or ceftriaxone) and ceftazidime (13, 14) and only the latter compounds are used in the confirmation testing.
LINK
Extended-spectrum beta-lactamases (ESBLs): treatment, prevention, surveillance
Gov.UK 2013
How to prevent the spread of extended-spectrum beta-lactamase (ESBL) producing E. coli and Klebsiella - and treatment options..
LINK
EUCAST guidelines for detection of resistance mechanisms Version 1.0 December 2013
EUCAST 2013
The recommended strategy for the detection of ESBLs in Enterobacteriaceae is based on non-susceptibility to indicator oxyiminocephalosporins, followed by phenotypic (and in some cases genotypic) confirmation tests.
LINK
EUCAST guidelines for detection of resistance mechanisms Version 2.0 July 2017
EUCAST 2017
Cefpodoxime is the most sensitive individual indicator cephalosporin for detection of ESBL production and may be used for screening. However, it is less specific than the combination of cefotaxime (or ceftriaxone) and ceftazidime (13, 14) and only the latter compounds are used in the confirmation testing.
LINK
ROSCO kits are compliant with the EUCAST guidelines. All products required by the ESBL & AmpC phenotyping algorithm are available in kit form. Interpretation software is available free of charge to ROSCO users
Why Rosco Neo-Sensitabs? Because stability means accuracy.
ASM MIcrobe - Stable Antibiotic Sensitivity Disks
ABSTRACT 'Two methods of preparing sensitivity disks were compared for their effect on disk stability at 25 and 37 C. One method consisted of applying a solution of the antibiotic to blank disks by the conventional procedure; the second method consisted of applying the antibiotic to the disks as a suspension of crystals. Of the four β-lactam antibiotics that were studied, disks made with suspended crystals were substantially more stable than corresponding disks made by the conventional method.'
ASM MIcrobe - Stable Antibiotic Sensitivity Disks
ABSTRACT 'Two methods of preparing sensitivity disks were compared for their effect on disk stability at 25 and 37 C. One method consisted of applying a solution of the antibiotic to blank disks by the conventional procedure; the second method consisted of applying the antibiotic to the disks as a suspension of crystals. Of the four β-lactam antibiotics that were studied, disks made with suspended crystals were substantially more stable than corresponding disks made by the conventional method.'
Why are most Neo-Sensitabs stable at room temperature?
Unlike paper discs we use the dry crystalline antimicrobial which is compacted into tablets.
Does stability mean better results?
A multi centre evaluation in UK hospitals showed good comparison between paper discs and Rosco tablets with 'stable' antibiotics but significantly better results obtained with Rosco tablets when the antibiotic was less stable (co-amoxyclav).
ASM MIcrobe - Stable Antibiotic Sensitivity Disks
ABSTRACT 'Two methods of preparing sensitivity disks were compared for their effect on disk stability at 25 and 37 C. One method consisted of applying a solution of the antibiotic to blank disks by the conventional procedure; the second method consisted of applying the antibiotic to the disks as a suspension of crystals. Of the four β-lactam antibiotics that were studied, disks made with suspended crystals were substantially more stable than corresponding disks made by the conventional method.'
Laboratory surveillance of CPGN bacteria (England): October 2020 to September 2022
Health Protection Report Volume 17 Number 2
Quarterly trends
The rate of acquired carbapenemase-producing Gram-negative bacteria reports by geographic area
Episodes of acquired carbapenemase-producing Gram-negative bacteria by species and carbapenemase family
Health Protection Report Volume 17 Number 2
Quarterly trends
The rate of acquired carbapenemase-producing Gram-negative bacteria reports by geographic area
Episodes of acquired carbapenemase-producing Gram-negative bacteria by species and carbapenemase family
